Epitalon
also known as Epithalon, Epithalamin synthetic, Ala-Glu-Asp-Gly
Synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed at the Saint Petersburg Institute of Bioregulation and Gerontology as the active analog of epithalamin, a natural pineal extract. Khavinson et al. demonstrated telomerase-activating and telomere-elongating activity in human somatic cells. Long-term safety + efficacy data are dominated by Russian-language literature; Western RCTs are sparse. Frequently used anecdotally for longevity and sleep regulation.
At a glance
SQ or IM · Abdomen · Daily for 10–20 days
Mechanism
Primary target — Telomerase activity (proposed); pineal melatonin axis modulation [khavinson-2003].
Pathway — Activation of telomerase reverse transcriptase (hTERT) in somatic cells; pineal-axis modulation supports endogenous melatonin [khavinson-2003].
Downstream effect — Telomere elongation, improved sleep architecture, reported lifespan extension in aged mice [khavinson-2003].
Origin — Synthetic 4-AA peptide derived from epithalamin (a natural pineal extract) [khavinson-2003].
Dosage
Protocols described in the cited literature; not medical advice.
| Parameter | Value |
|---|---|
| Standard dose | 5–10 mg / day for 10–20 days, 1–2× per year [khavinson-2003]Anecdotal community protocol. Russian clinical literature uses similar cycling. |
| Frequency | Once daily during a cycle |
| Lower / starter dose | 2.5 mg / day |
| Evidence basis | In-vitro telomerase + Russian clinical trials [khavinson-2003] |
| Duration | 10–20 day cycles, 1–2× per year |
| Reconstitution | Bacteriostatic water |
| Timing | Pre-sleep preferred (pineal alignment) |
| Half-life | Hours (estimated) |
Reconstitution
A pure mass-to-volume utility. Enter what you have in the vial; the atlas computes the volume per dose. No prescription information.
Adverse events
Severities follow the FDA / CTCAE convention.
- — Pregnancy / breastfeeding
- — Active malignancy or pre-malignant state
- — Family history of cancer
Administration
- 01Reconstitution
Add 1–2 mL bacteriostatic water to 10 mg vial → 5–10 mg/mL.
- 02Injection site
SQ — abdomen preferred. Rotate sites.
- 03Timing
Pre-sleep preferred to align with pineal axis.
- 04Storage
Lyophilised: room temp, light-protected. Reconstituted: refrigerate ≤30 days.
- 05Needle
29–31G, 4–8 mm insulin syringe.
Sources
of 37 rendered claims carry a resolvable citation.
- [khavinson-2003]Khavinson 2003 — Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Bull Exp Biol Med, 2003